Diabetic patients who took high doses of folic acid, B6 and B12 had increased kidney damage and double the risk of heart attacks and strokes.
water-soluble B vitamins are normally filtered through the kidneys. It may be that in people with kidney failure, the vitamins cannot be process adequately so that they build up to toxic levels.
Vitamins are really powerful chemicals, so just the fact that they’re natural doesn’t mean that high doses are always going to be OK,

Journal of the American Medical Association
